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Protein–DNA binding specificity predictions with structural models

Protein–DNA interactions play a central role in transcriptional regulation and other biological processes. Investigating the mechanism of binding affinity and specificity in protein–DNA complexes is thus an important goal. Here we develop a simple physical energy function, which uses electrostatics,...

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Detalhes bibliográficos
Main Authors: Morozov, Alexandre V., Havranek, James J., Baker, David, Siggia, Eric D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1270944/
https://ncbi.nlm.nih.gov/pubmed/16246914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki875
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