Fourteen-Member Macrolides Suppress Interleukin-8 Production but Do Not Promote Apoptosis of Activated Neutrophils

A 14-member macrolide was found to inhibit interleukin-8 (IL-8) synthesis in lipopolysaccharide-stimulated neutrophils but did not accelerate apoptosis in activated neutrophils. These data suggest that 14-member macrolides achieve clinical efficacy for chronic airway diseases partly by suppressing I...

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Autori principali: Tsuchihashi, Yoshiko, Oishi, Kazunori, Yoshimine, Hiroyuki, Suzuki, Shoichi, Kumatori, Atsushi, Sunazuka, Toshiaki, Omura, Satoshi, Matsushima, Kouji, Nagatake, Tsuyoshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Biologic Response Modifiers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC127094/
https://ncbi.nlm.nih.gov/pubmed/11897597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.4.1101-1104.2002
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