Mutations Affecting the Rossman Fold of Isoleucyl-tRNA Synthetase Are Correlated with Low-Level Mupirocin Resistance in Staphylococcus aureus

The isoleucyl-tRNA synthetase (ileS) gene was sequenced in toto from 9 and in part from 31 Staphylococcus aureus strains with various degrees of susceptibility to mupirocin. All strains for which the mupirocin MIC was greater than 8 μg/ml contained point mutations affecting the Rossman fold via Val-...

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הוצא לאור ב:	Antimicrob Agents Chemother
Principais autores:	Antonio, Martin, McFerran, Neil, Pallen, Mark J.
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2002
נושאים:	Mechanisms of Resistance
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127053/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796355/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.438-442.2002
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