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Mutations Affecting the Rossman Fold of Isoleucyl-tRNA Synthetase Are Correlated with Low-Level Mupirocin Resistance in Staphylococcus aureus

The isoleucyl-tRNA synthetase (ileS) gene was sequenced in toto from 9 and in part from 31 Staphylococcus aureus strains with various degrees of susceptibility to mupirocin. All strains for which the mupirocin MIC was greater than 8 μg/ml contained point mutations affecting the Rossman fold via Val-...

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書誌詳細
主要な著者: Antonio, Martin, McFerran, Neil, Pallen, Mark J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC127053/
https://ncbi.nlm.nih.gov/pubmed/11796355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.2.438-442.2002
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