Inhibitory Effect of Adefovir on Viral DNA Synthesis and Covalently Closed Circular DNA Formation in Duck Hepatitis B Virus-Infected Hepatocytes In Vivo and In Vitro

The elimination of viral covalently closed circular DNA (CCC DNA) from the nucleus of infected hepatocytes is an obstacle to achieving sustained viral clearance during antiviral therapy of chronic hepatitis B virus (HBV) infection. The aim of our study was to determine whether treatment with adefovi...

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Autores principales: Delmas, Julien, Schorr, Olivier, Jamard, Catherine, Gibbs, Craig, Trépo, Christian, Hantz, Olivier, Zoulim, Fabien
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC127044/
https://ncbi.nlm.nih.gov/pubmed/11796353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.2.425-433.2002
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