2',3'-dideoxy-beta-L-5-fluorocytidine inhibits duck hepatitis B virus reverse transcription and suppresses viral DNA synthesis in hepatocytes, both in vitro and in vivo.

beta-L-Nucleoside analogs represent a new class of potent antiviral agents with low cytotoxicity which provide new hope in the therapy of chronic hepatitis B virus (HBV) infections. We evaluated the anti-HBV activity of 2',3'-dideoxy-beta-L-5-fluorocytidine (beta-L-F-ddC), a beta-L-nucleoside analog...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Zoulim, F, Dannaoui, E, Borel, C, Hantz, O, Lin, T S, Liu, S H, Trépo, C, Cheng, Y C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC163132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8834896/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.40.2.448
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