Efficacy of TAK-457, a Novel Intravenous Triazole, against Invasive Pulmonary Aspergillosis in Neutropenic Mice

TAK-457 is an injectable prodrug of TAK-456, which is a novel oral triazole compound with potent antifungal activity. The in vivo efficacy of TAK-457 was evaluated in two models of invasive pulmonary aspergillosis with CDF(1) mice and CBA/J mice with transient neutropenia induced by cyclophosphamide...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Hayashi, Ryogo, Kitamoto, Naomi, Iizawa, Yuji, Ichikawa, Takashi, Itoh, Katsumi, Kitazaki, Tomoyuki, Okonogi, Kenji
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC127021/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11796331/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.2.283-287.2002
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