Gentamicin Increases the Efficacy of Vancomycin against Penicillin-Resistant Pneumococci in the Rabbit Meningitis Model

In experimental meningitis a single dose of gentamicin (10 mg/kg of body weight) led to gentamicin levels in around cerebrospinal fluid (CSF) of 4 mg/liter for 4 h, decreasing slowly to 2 mg/liter 4 h later. The CSF penetration of gentamicin ranged around 27%, calculated by comparison of areas under...

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Bibliographic Details
Main Authors: Cottagnoud, Philippe, Gerber, Cynthia M., Cottagnoud, Marianne, Täuber, Martin G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2002
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC127013/
https://ncbi.nlm.nih.gov/pubmed/11751132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.1.188-190.2002
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