Efficacies of BMS 284756 against Penicillin-Sensitive, Penicillin-Resistant, and Quinolone-Resistant Pneumococci in Experimental Meningitis

BMS 284756 penetrated well into inflamed meninges (44% ± 11%) and produced good bactericidal activity (−0.82 ± 0.22 Δlog(10) CFU/ml · h) in the treatment of experimental meningitis in rabbits due to a penicillin-sensitive strain. BMS 284756 monotherapy had a greater potency than the standard regimen...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Cottagnoud, Philippe, Acosta, Fernando, Cottagnoud, Marianne, Pfister, Marc, Täuber, Martin G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2002
Soggetti:	Experimental Therapeutics
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126974/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11751131/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.46.1.184-187.2002
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