Biodegradation of 1,2,3-Trichloropropane through Directed Evolution and Heterologous Expression of a Haloalkane Dehalogenase Gene

Using a combined strategy of random mutagenesis of haloalkane dehalogenase and genetic engineering of a chloropropanol-utilizing bacterium, we constructed an organism that is capable of growth on 1,2,3-trichloropropane (TCP). This highly toxic and recalcitrant compound is a waste product generated f...

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Vydáno v:	Appl Environ Microbiol
Hlavní autoři:	Bosma, Tjibbe, Damborský, Jir̆í, Stucki, Gerhard, Janssen, Dick B.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2002
Témata:	Enzymology and Protein Engineering
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126774/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12089046/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.68.7.3582-3587.2002
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