Biodegradation of 1,2,3-Trichloropropane through Directed Evolution and Heterologous Expression of a Haloalkane Dehalogenase Gene

Using a combined strategy of random mutagenesis of haloalkane dehalogenase and genetic engineering of a chloropropanol-utilizing bacterium, we constructed an organism that is capable of growth on 1,2,3-trichloropropane (TCP). This highly toxic and recalcitrant compound is a waste product generated f...

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Detalhes bibliográficos

Publicado no:	Appl Environ Microbiol
Principais autores:	Bosma, Tjibbe, Damborský, Jir̆í, Stucki, Gerhard, Janssen, Dick B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2002
Assuntos:	Enzymology and Protein Engineering
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126774/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12089046/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AEM.68.7.3582-3587.2002
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