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Regulation of Epidermal Growth Factor Receptor Down-Regulation by UBPY-mediated Deubiquitination at Endosomes

Ligand-activated receptor tyrosine kinases undergo endocytosis and are transported via endosomes to lysosomes for degradation. This “receptor down-regulation” process is crucial to terminate the cell proliferation signals produced by activated receptors. During the process, ubiquitination of the rec...

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Bibliographic Details
Main Authors: Mizuno, Emi, Iura, Takanobu, Mukai, Akiko, Yoshimori, Tamotsu, Kitamura, Naomi, Komada, Masayuki
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1266416/
https://ncbi.nlm.nih.gov/pubmed/16120644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E05-06-0560
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