CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms

CTLA-4 and PD-1 are receptors that negatively regulate T-cell activation. Ligation of both CTLA-4 and PD-1 blocked CD3/CD28-mediated upregulation of glucose metabolism and Akt activity, but each accomplished this regulation using separate mechanisms. CTLA-4-mediated inhibition of Akt phosphorylation...

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Detalhes bibliográficos
Main Authors: Parry, Richard V., Chemnitz, Jens M., Frauwirth, Kenneth A., Lanfranco, Anthony R., Braunstein, Inbal, Kobayashi, Sumire V., Linsley, Peter S., Thompson, Craig B., Riley, James L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265804/
https://ncbi.nlm.nih.gov/pubmed/16227604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.21.9543-9553.2005
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