SOCS2 Can Enhance Interleukin-2 (IL-2) and IL-3 Signaling by Accelerating SOCS3 Degradation

Cytokine responses can be regulated by a family of proteins termed suppressors of cytokine signaling (SOCS) which can inhibit the JAK/STAT pathway in a classical negative-feedback manner. While the SOCS are thought to target signaling intermediates for degradation, relatively little is known about h...

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Main Authors: Tannahill, Gillian M., Elliott, Joanne, Barry, Anna C., Hibbert, Linda, Cacalano, Nicolas A., Johnston, James A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1265772/
https://ncbi.nlm.nih.gov/pubmed/16199887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.20.9115-9126.2005
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