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Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Aβ, in the brain. Aβ arises from cleavage of the Amyloid Precursor protein by β and γ secretases, which present attractive candidates for therapeutic targeting. Two β-secretase candidates...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2002
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126479/ https://ncbi.nlm.nih.gov/pubmed/12204094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-3-25 |
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