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Dual mode of degradation of Cdc25 A phosphatase

The Cdc25 dual-specificity phosphatases control progression through the eukaryotic cell division cycle by activating cyclin-dependent kinases. Cdc25 A regulates entry into S-phase by dephosphorylating Cdk2, it cooperates with activated oncogenes in inducing transformation and is overexpressed in sev...

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Autors principals: Donzelli, Maddalena, Squatrito, Massimo, Ganoth, Dvora, Hershko, Avram, Pagano, Michele, Draetta, Giulio F.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2002
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC126287/
https://ncbi.nlm.nih.gov/pubmed/12234927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf491
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