A COOH-terminal peptide confers regiospecific orientation and facilitates atomic force microscopy of an IgG1.

An antibody (IgG1) was designed for oriented adherence to a metal-containing surface. This was achieved by adding a metal-chelating peptide, (CP = His-Trp-His-His-His-Pro), to the COOH-terminus of the heavy chain through genetic engineering. Electroporation of the engineered heavy chain gene into ce...

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Hlavní autoři: Ill, C R, Keivens, V M, Hale, J E, Nakamura, K K, Jue, R A, Cheng, S, Melcher, E D, Drake, B, Smith, M C
Médium: Artigo
Jazyk:Inglês
Vydáno: 1993
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1262406/
https://ncbi.nlm.nih.gov/pubmed/8471734
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