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Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope

Syncytia arising from the fusion of cells expressing the HIV-1-encoded Env gene with cells expressing the CD4/CXCR4 complex undergo apoptosis following the nuclear translocation of mammalian target of rapamycin (mTOR), mTOR-mediated phosphorylation of p53 on Ser15 (p53(S15)), p53-dependent upregulat...

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Publicat a:EMBO J
Autors principals: Castedo, Maria, Roumier, Thomas, Blanco, Julià, Ferri, Karine F., Barretina, Jordi, Tintignac, Lionel A., Andreau, Karine, Perfettini, Jean-Luc, Amendola, Alessandra, Nardacci, Roberta, Leduc, Philip, Ingber, Donald E., Druillennec, Sabine, Roques, Bernard, Leibovitch, Serge A., Vilella-Bach, Montserrat, Chen, Jie, Este, José A., Modjtahedi, Nazanine, Piacentini, Mauro, Kroemer, Guido
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2002
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126138/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12145207/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf391
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