Essential role of PDK1 in regulating cell size and development in mice

PDK1 functions as a master kinase, phosphorylating and activating PKB/Akt, S6K and RSK. To learn more about the roles of PDK1, we generated mice that either lack PDK1 or possess PDK1 hypomorphic alleles, expressing only ∼10% of the normal level of PDK1. PDK1(–/–) embryos die at embryonic day 9.5, di...

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Detalhes bibliográficos
Main Authors: Lawlor, Margaret A., Mora, Alfonso, Ashby, Peter R., Williams, Michayla R., Murray-Tait, Victoria, Malone, Lorraine, Prescott, Alan R., Lucocq, John M., Alessi, Dario R.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126129/
https://ncbi.nlm.nih.gov/pubmed/12110585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf387
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