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Deconstructing PML-induced premature senescence

In this study, we investigated the subcellular and molecular mechanisms underlying promyelocytic leu kemia (PML)-induced premature senescence. We demonstrate that intact PML nuclear bodies are not required for the induction of senescence. We have determined further that of seven known PML isoforms,...

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Autors principals: Bischof, Oliver, Kirsh, Olivier, Pearson, Mark, Itahana, Koji, Pelicci, Pier Giuseppe, Dejean, Anne
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2002
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC126090/
https://ncbi.nlm.nih.gov/pubmed/12093737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf341
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