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Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development
Correct cell cycle regulation and terminal mitosis are critical for nervous system development. The retinoblastoma (Rb) protein is a key regulator of these processes, as Rb–/– embryos die by E15.5, exhibiting gross hematopoietic and neurological defects. The extensive apoptosis in Rb–/– embryos has...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2002
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126087/ https://ncbi.nlm.nih.gov/pubmed/12093735 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf338 |
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