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Telencephalon-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal cortical development

Correct cell cycle regulation and terminal mitosis are critical for nervous system development. The retinoblastoma (Rb) protein is a key regulator of these processes, as Rb–/– embryos die by E15.5, exhibiting gross hematopoietic and neurological defects. The extensive apoptosis in Rb–/– embryos has...

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Detalhes bibliográficos
Main Authors: Ferguson, Kerry L., Vanderluit, Jacqueline L., Hébert, Jean M., McIntosh, W.C., Tibbo, Emma, MacLaurin, Jason G., Park, David S., Wallace, Valerie A., Vooijs, Marc, McConnell, Susan K., Slack, Ruth S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126087/
https://ncbi.nlm.nih.gov/pubmed/12093735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf338
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