The yeast prion Ure2p retains its native α-helical conformation upon assembly into protein fibrils in vitro

The yeast inheritable phenotype [URE3] is thought to result from conformational changes in the normally soluble and highly helical protein Ure2p. In vitro, the protein spontaneously forms long, straight, insoluble protein fibrils at neutral pH. Here we show that fibrils of intact Ure2p assembled in...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Bousset, Luc, Thomson, Neil H., Radford, Sheena E., Melki, Ronald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf303
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