The yeast prion Ure2p retains its native α-helical conformation upon assembly into protein fibrils in vitro

The yeast inheritable phenotype [URE3] is thought to result from conformational changes in the normally soluble and highly helical protein Ure2p. In vitro, the protein spontaneously forms long, straight, insoluble protein fibrils at neutral pH. Here we show that fibrils of intact Ure2p assembled in...

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Bibliographic Details

Published in:	EMBO J
Main Authors:	Bousset, Luc, Thomson, Neil H., Radford, Sheena E., Melki, Ronald
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2002
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf303
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