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The yeast prion Ure2p retains its native α-helical conformation upon assembly into protein fibrils in vitro
The yeast inheritable phenotype [URE3] is thought to result from conformational changes in the normally soluble and highly helical protein Ure2p. In vitro, the protein spontaneously forms long, straight, insoluble protein fibrils at neutral pH. Here we show that fibrils of intact Ure2p assembled in...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Oxford University Press
2002
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC126058/ https://ncbi.nlm.nih.gov/pubmed/12065404 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf303 |
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