The yeast prion Ure2p retains its native α-helical conformation upon assembly into protein fibrils in vitro

The yeast inheritable phenotype [URE3] is thought to result from conformational changes in the normally soluble and highly helical protein Ure2p. In vitro, the protein spontaneously forms long, straight, insoluble protein fibrils at neutral pH. Here we show that fibrils of intact Ure2p assembled in...

Täydet tiedot

Bibliografiset tiedot

Julkaisussa:	EMBO J
Päätekijät:	Bousset, Luc, Thomson, Neil H., Radford, Sheena E., Melki, Ronald
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Publishing Group 2002
Aiheet:	Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126058/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12065404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdf303
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