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The yeast prion Ure2p retains its native α-helical conformation upon assembly into protein fibrils in vitro

The yeast inheritable phenotype [URE3] is thought to result from conformational changes in the normally soluble and highly helical protein Ure2p. In vitro, the protein spontaneously forms long, straight, insoluble protein fibrils at neutral pH. Here we show that fibrils of intact Ure2p assembled in...

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Detalhes bibliográficos
Main Authors: Bousset, Luc, Thomson, Neil H., Radford, Sheena E., Melki, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC126058/
https://ncbi.nlm.nih.gov/pubmed/12065404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdf303
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