Crystal structure of the tetrameric Mad1–Mad2 core complex: implications of a ‘safety belt’ binding mechanism for the spindle checkpoint

The spindle checkpoint protein Mad1 recruits Mad2 to unattached kinetochores and is essential for Mad2–Cdc20 complex formation in vivo but not in vitro. The crystal structure of the Mad1–Mad2 complex reveals an asymmetric tetramer, with elongated Mad1 monomers parting from a coiled-coil to form two...

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I whakaputaina i:	EMBO J
Ngā kaituhi matua:	Sironi, Lucia, Mapelli, Marina, Knapp, Stefan, Antoni, Anna De, Jeang, Kuan-Teh, Musacchio, Andrea
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Publishing Group 2002
Ngā marau:	Article
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC126000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12006501/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.10.2496
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