Activation of the Aspergillus PacC zinc finger transcription factor requires two proteolytic steps

The Aspergillus PacC transcription factor undergoes proteolytic activation in response to alkaline ambient pH. In acidic environments, the 674 residue translation product adopts a ‘closed’ conformation, protected from activation through intramolecular interactions involving the ≤150 residue C-termin...

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Autores principales: Díez, Eliecer, Álvaro, Josué, Espeso, Eduardo A., Rainbow, Lynne, Suárez, Teresa, Tilburn, Joan, Arst, Herbert N., Peñalva, Miguel Á.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2002
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC125927/
https://ncbi.nlm.nih.gov/pubmed/11889040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.6.1350
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