Activation of the Aspergillus PacC zinc finger transcription factor requires two proteolytic steps

The Aspergillus PacC transcription factor undergoes proteolytic activation in response to alkaline ambient pH. In acidic environments, the 674 residue translation product adopts a ‘closed’ conformation, protected from activation through intramolecular interactions involving the ≤150 residue C-termin...

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Autori principali: Díez, Eliecer, Álvaro, Josué, Espeso, Eduardo A., Rainbow, Lynne, Suárez, Teresa, Tilburn, Joan, Arst, Herbert N., Peñalva, Miguel Á.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC125927/
https://ncbi.nlm.nih.gov/pubmed/11889040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.6.1350
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