The rhesus rotavirus VP4 sialic acid binding domain has a galectin fold with a novel carbohydrate binding site

Cell attachment and membrane penetration are functions of the rotavirus outer capsid spike protein, VP4. An activating tryptic cleavage of VP4 produces the N-terminal fragment, VP8*, which is the viral hemagglutinin and an important target of neutralizing antibodies. We have determined, by X-ray cry...

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Pubblicato in:	EMBO J
Autori principali:	Dormitzer, Philip R., Sun, Zhen-Yu J., Wagner, Gerhard, Harrison, Stephen C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125907/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867517/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.5.885
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