Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

The biological activity of the soluble form of the Notch ligand (sNL) and requirement of the intracellular domain (ICD) of the Notch ligand have been debated. Here we show that soluble Delta1 (sD1) activates Notch2 (N2), but much more weakly than full-length Delta1 (fD1). Furthermore, tracing the N2...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Shimizu, Kiyoshi, Chiba, Shigeru, Saito, Toshiki, Takahashi, Tokiharu, Kumano, Keiki, Hamada, Yoshio, Hirai, Hisamaru
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11823422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.3.294
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