Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

The biological activity of the soluble form of the Notch ligand (sNL) and requirement of the intracellular domain (ICD) of the Notch ligand have been debated. Here we show that soluble Delta1 (sD1) activates Notch2 (N2), but much more weakly than full-length Delta1 (fD1). Furthermore, tracing the N2...

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Bibliographic Details
Main Authors: Shimizu, Kiyoshi, Chiba, Shigeru, Saito, Toshiki, Takahashi, Tokiharu, Kumano, Keiki, Hamada, Yoshio, Hirai, Hisamaru
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC125840/
https://ncbi.nlm.nih.gov/pubmed/11823422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.3.294
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