Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

The biological activity of the soluble form of the Notch ligand (sNL) and requirement of the intracellular domain (ICD) of the Notch ligand have been debated. Here we show that soluble Delta1 (sD1) activates Notch2 (N2), but much more weakly than full-length Delta1 (fD1). Furthermore, tracing the N2...

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Pubblicato in:	EMBO J
Autori principali:	Shimizu, Kiyoshi, Chiba, Shigeru, Saito, Toshiki, Takahashi, Tokiharu, Kumano, Keiki, Hamada, Yoshio, Hirai, Hisamaru
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2002
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125840/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11823422/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.3.294
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