Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3

Cyclin-dependent kinase 5 (cdk5) is a serine/threonine kinase activated by associating with its neuron-specific activators p35 and p39. Analysis of cdk5(–/–) and p35(–/–) mice has demonstrated that both cdk5 and p35 are essential for neuronal migration, axon pathfinding and the laminar configuration...

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Publicat a:	EMBO J
Autors principals:	Li, Bing-Sheng, Zhang, Lei, Takahashi, Satoru, Ma, Wu, Jaffe, Howard, Kulkarni, Ashok B., Pant, Harish C.
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2002
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125822/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11823425/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.3.324
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