PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2
Heregulin (HRG)-induced tyrosine phosphorylation of the Gab2 docking protein was enhanced by pretreatment with wortmannin, indicating negative regulation via a PI3-kinase-dependent pathway. This represents phosphorylation by the serine/threonine kinase protein kinase B (PKB), since PKB constitutivel...
Gespeichert in:
| Veröffentlicht in: | EMBO J |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2002
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125816/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782427/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.1.72 |
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