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PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2
Heregulin (HRG)-induced tyrosine phosphorylation of the Gab2 docking protein was enhanced by pretreatment with wortmannin, indicating negative regulation via a PI3-kinase-dependent pathway. This represents phosphorylation by the serine/threonine kinase protein kinase B (PKB), since PKB constitutivel...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125816/ https://ncbi.nlm.nih.gov/pubmed/11782427 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.1.72 |
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