PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2

Heregulin (HRG)-induced tyrosine phosphorylation of the Gab2 docking protein was enhanced by pretreatment with wortmannin, indicating negative regulation via a PI3-kinase-dependent pathway. This represents phosphorylation by the serine/threonine kinase protein kinase B (PKB), since PKB constitutivel...

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Bibliografske podrobnosti

izdano v:	EMBO J
Principais autores:	Lynch, Danielle K., Daly, Roger J.
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Publishing Group 2002
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125816/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782427/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/21.1.72
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