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T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts
The nonsense-mediated decay (NMD) RNA surveillance pathway detects and degrades mRNAs containing premature termination codons (PTCs). T-cell receptor (TCR) and immunoglobulin transcripts, which commonly harbor PTCs as a result of programmed DNA rearrangement during normal development, are down-regul...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2002
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125808/ https://ncbi.nlm.nih.gov/pubmed/11782432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/21.1.125 |
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