A highly selective telomerase inhibitor limiting human cancer cell proliferation

Telomerase, the ribonucleoprotein enzyme maintaining the telomeres of eukaryotic chromosomes, is active in most human cancers and in germline cells but, with few exceptions, not in normal human somatic tissues. Telomere maintenance is essential to the replicative potential of malignant cells and the...

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Autori principali: Damm, Klaus, Hemmann, Ulrike, Garin-Chesa, Pilar, Hauel, Norbert, Kauffmann, Iris, Priepke, Henning, Niestroj, Claudia, Daiber, Christine, Enenkel, Barbara, Guilliard, Bernd, Lauritsch, Ines, Müller, Elfriede, Pascolo, Emanuelle, Sauter, Gabriele, Pantic, Milena, Martens, Uwe M., Wenz, Christian, Lingner, Joachim, Kraut, Norbert, Rettig, Wolfgang J., Schnapp, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2001
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC125790/
https://ncbi.nlm.nih.gov/pubmed/11742973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.24.6958
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