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Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism

Thioredoxin reductase (TrxR) is an essential enzyme required for the efficient maintenance of the cellular redox homeostasis, particularly in cancer cells that are sensitive to reactive oxygen species. In mammals, distinct isozymes function in the cytosol and mitochondria. Through an intricate mecha...

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Autori principali: Biterova, Ekaterina I., Turanov, Anton A., Gladyshev, Vadim N., Barycki, Joseph J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257698/
https://ncbi.nlm.nih.gov/pubmed/16217027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0504218102
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