Developmental Exposure of Rats to Chlorpyrifos Leads to Behavioral Alterations in Adulthood, Involving Serotonergic Mechanisms and Resembling Animal Models of Depression

Developmental exposure to chlorpyrifos (CPF) causes persistent changes in serotonergic (5HT) systems. We administered 1 mg/kg/day CPF to rats on postnatal days 1–4, a regimen below the threshold for systemic toxicity. When tested in adulthood, CPF-exposed animals showed abnormalities in behavioral t...

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Detalhes bibliográficos
Main Authors: Aldridge, Justin E., Levin, Edward D., Seidler, Frederic J., Slotkin, Theodore A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institue of Environmental Health Sciences 2005
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257542/
https://ncbi.nlm.nih.gov/pubmed/15866758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.7867
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