Developmental Exposure of Rats to Chlorpyrifos Leads to Behavioral Alterations in Adulthood, Involving Serotonergic Mechanisms and Resembling Animal Models of Depression

Developmental exposure to chlorpyrifos (CPF) causes persistent changes in serotonergic (5HT) systems. We administered 1 mg/kg/day CPF to rats on postnatal days 1–4, a regimen below the threshold for systemic toxicity. When tested in adulthood, CPF-exposed animals showed abnormalities in behavioral t...

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Autores principales: Aldridge, Justin E., Levin, Edward D., Seidler, Frederic J., Slotkin, Theodore A.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Institue of Environmental Health Sciences 2005
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257542/
https://ncbi.nlm.nih.gov/pubmed/15866758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.7867
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