Tyrosine phosphorylation of Grb2 by Bcr/Abl and epidermal growth factor receptor: a novel regulatory mechanism for tyrosine kinase signaling

Growth factor receptor-binding protein-2 (Grb2) plays a key role in signal transduction initiated by Bcr/Abl oncoproteins and growth factors, functioning as an adaptor protein through its Src homology 2 and 3 (SH2 and SH3) domains. We found that Grb2 was tyrosine-phosphorylated in cells expressing B...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Li, Shaoguang, Couvillon, Anthony D., Brasher, Bradley B., Van Etten, Richard A.
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2001
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125747/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11726515/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.23.6793
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