Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

The mechanisms by which microvascular damage leads to dermal fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) are unclear. We hypothesized that microvascular pericytes constitute a cellular link between microvascular damage and fibrosis by transdifferentiating into myofibroblasts. We used a...

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Main Authors: Rajkumar, Vineeth S, Howell, Kevin, Csiszar, Katalin, Denton, Christopher P, Black, Carol M, Abraham, David J
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257439/
https://ncbi.nlm.nih.gov/pubmed/16207328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1790
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