The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases

This study sought to evaluate the levels of mRNA expression and protein synthesis of MMP-13, cathepsin K, aggrecanase-1 (ADAMTS-4), aggrecanase-2 (ADAMTS-5) and 5-lipoxygenase (5-LOX) in cartilage in the experimental anterior cruciate ligament (ACL) dog model of osteoarthritis (OA), and to examine t...

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Bibliographic Details
Main Authors: Pelletier, Jean-Pierre, Boileau, Christelle, Boily, Martin, Brunet, Julie, Mineau, François, Geng, Changshen, Reboul, Pascal, Laufer, Stefan, Lajeunesse, Daniel, Martel-Pelletier, Johanne
Format: Artigo
Language:Inglês
Published: BioMed Central 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1257437/
https://ncbi.nlm.nih.gov/pubmed/16207326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1788
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