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Activation of Cdh1-dependent APC is required for G(1) cell cycle arrest and DNA damage-induced G(2) checkpoint in vertebrate cells
Anaphase-promoting complex (APC) is activated by two regulatory proteins, Cdc20 and Cdh1. In yeast and Drosophila, Cdh1-dependent APC (Cdh1–APC) activity targets mitotic cyclins from the end of mitosis to the G(1) phase. To investigate the function of Cdh1 in vertebrate cells, we generated clones of...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125730/ https://ncbi.nlm.nih.gov/pubmed/11707420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.22.6499 |
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