Molecular mechanisms of β-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC–β-catenin complex
The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product β-catenin. APC binds to β-catenin through a series of homologous 15 and 20 amino acid repeats. We have determined the crystal structure of a 15 amino acid β-caten...
Shranjeno v:
| izdano v: | EMBO J |
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| Principais autores: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6203 |
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