Molecular mechanisms of β-catenin recognition by adenomatous polyposis coli revealed by the structure of an APC–β-catenin complex

The adenomatous polyposis coli (APC) tumor suppressor protein plays a critical role in regulating cellular levels of the oncogene product β-catenin. APC binds to β-catenin through a series of homologous 15 and 20 amino acid repeats. We have determined the crystal structure of a 15 amino acid β-caten...

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Pubblicato in:	EMBO J
Autori principali:	Spink, Katharine Eklof, Fridman, Sofiya G., Weis, William I.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11707392/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.22.6203
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