Cystinosin, the protein defective in cystinosis, is a H(+)-driven lysosomal cystine transporter

Cystinosis is an inherited lysosomal storage disease characterized by defective transport of cystine out of lysosomes. However, the causative gene, CTNS, encodes a seven transmembrane domain lysosomal protein, cystinosin, unrelated to known transporters. To investigate the molecular function of cyst...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Kalatzis, Vasiliki, Cherqui, Stéphanie, Antignac, Corinne, Gasnier, Bruno
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2001
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125690/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11689434/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.21.5940
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