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Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells
Adenomatous polyposis coli (APC) is mutated in most colorectal cancers. APC downregulates nuclear β-catenin, which is thought to be critical for its tumour suppressor function. However, APC may have additional and separate functions at the cell periphery. Here, we examine polarized MDCK and WIF-B he...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2001
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC125686/ https://ncbi.nlm.nih.gov/pubmed/11689433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.21.5929 |
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