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Actin-dependent membrane association of the APC tumour suppressor in polarized mammalian epithelial cells

Adenomatous polyposis coli (APC) is mutated in most colorectal cancers. APC downregulates nuclear β-catenin, which is thought to be critical for its tumour suppressor function. However, APC may have additional and separate functions at the cell periphery. Here, we examine polarized MDCK and WIF-B he...

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Bibliografische gegevens
Hoofdauteurs: Rosin-Arbesfeld, Rina, Ihrke, Gudrun, Bienz, Mariann
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2001
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC125686/
https://ncbi.nlm.nih.gov/pubmed/11689433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.21.5929
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