Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

P-glycoprotein (P-gp) is an ABC (ATP-binding cassette) transporter, which hydrolyses ATP and extrudes cytotoxic drugs from mammalian cells. P-gp consists of two transmembrane domains (TMDs) that span the membrane multiple times, and two cytoplasmic nucleotide-binding domains (NBDs). We have determin...

ver descrição completa

Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Rosenberg, Mark F., Velarde, Giles, Ford, Robert C., Martin, Catherine, Berridge, Georgina, Kerr, Ian D., Callaghan, Richard, Schmidlin, Andreas, Wooding, Carol, Linton, Kenneth J., Higgins, Christopher F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125677/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11598005/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.20.5615
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!