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Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle

P-glycoprotein (P-gp) is an ABC (ATP-binding cassette) transporter, which hydrolyses ATP and extrudes cytotoxic drugs from mammalian cells. P-gp consists of two transmembrane domains (TMDs) that span the membrane multiple times, and two cytoplasmic nucleotide-binding domains (NBDs). We have determin...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Rosenberg, Mark F., Velarde, Giles, Ford, Robert C., Martin, Catherine, Berridge, Georgina, Kerr, Ian D., Callaghan, Richard, Schmidlin, Andreas, Wooding, Carol, Linton, Kenneth J., Higgins, Christopher F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2001
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Article
Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125677/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11598005/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.20.5615
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