Proteasomes and ubiquitin are involved in the turnover of the wild-type prion protein
Prion diseases propagate by converting a normal glycoprotein of the host, PrP(C), into a pathogenic ‘prion’ conformation. Several misfolding mutants of PrP(C) are degraded through the ER-associated degradation (ERAD)–proteasome pathway. In their infectious form, prion diseases such as bovine spongif...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | EMBO J |
|---|---|
| Prif Awduron: | , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Nature Publishing Group
2001
|
| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC125653/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11574470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/20.19.5383 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
|